Upstream Processing Technician

Introduction Our client is a leading national research and innovation organization advancing human health through cutting-edge biotherapeutics and vaccines, offering the stability of the public sector with the innovation of a high-tech biotech environment. As an Upstream Processing (USP) Technician , you will support the manufacture of clinical biologics under current Good Manufacturing Practices (cGMP). You’ll work hands-on with mammalian cell culture, bioreactors, and upstream operations to produce material for clinical studies in a highly regulated, team-oriented environment. Responsibilities Execute upstream manufacturing steps according to batch records and cGMP requirements Perform mammalian cell culture operations, including propagation, expansion, and clinical-scale production in bioreactors Carry out in-process testing using spectrophotometers, pH meters, metabolite analyzers, and related lab equipment Perform master cell bank manufacturing and filling under biosafety cabinet conditions Weigh, transfer, and mix chemicals and media components according to procedures Set up, install, and operate single-use assemblies and related upstream processing equipment Conduct product filtration, centrifugation, and related upstream clarification steps Prepare and organize glassware and disposable assemblies for production runs Verify instrument calibration status prior to each production batch and document results Complete and review logbooks and other GMP documentation, performing corrections as required Support cleaning and autoclave activities in collaboration with production support teams Monitor stocks of common lab supplies and notify management of inventory needs Respond to emergency notifications following established procedures Participate in CAPA, Change Control, and Deviation reporting activities as needed Requirements Diploma or degree in Biotechnology, Biology, Biochemistry, or related life science (or equivalent experience in GMP manufacturing) Experience with mammalian cell culture and aseptic techniques (academic, co-op, or industry) Familiarity with cGMP, batch records, and controlled documentation practices Comfort working with bioreactors, filtration systems, and common analytical instruments (e.g., pH meters, spectrophotometers) Strong attention to detail and commitment to data integrity and product quality Ability to follow SOPs precisely and maintain accurate documentation Team-oriented mindset with good communication skills and willingness to support cross-functional activities Flexibility to work in a regulated, production-driven environment (shift work or occasional off-hours may be required) What We Offer Why apply through Brunel? Finding the next step in your career can be a full-time job in itself. We manage the process for you: from submitting your resume to coordinating interviews to extending offers and assisting with onboarding. We’ll get you going while you get on with the job. About Us Brunel has a reputation for working with some of the best in the business. That’s what we continually strive for. Over 45 years, we’ve created a global network of interesting clients and talented individuals working together through a vast array of services.

Location: Montreal, Quebec, CA

Posted Date: 11/18/2025